TSPO

Across TCGA pan-cancer cohorts, TSPO RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TSPO’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TSPO RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSPO is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

KIRP, KIRC, and LUAD are the cancer types where TSPO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.164	<.001	11	view →
KIRC	All	IV	+0.889	<.001	11	view →
LUAD	Male	All	−0.920	<.001	9	view →
CHOL	Female	All	+3.090	<.001	5	view →
LIHC	Male	II,III,IV	+1.319	<.001	5	view →
THCA	Male	All	+0.629	<.001	5	view →
COAD	Female	II,III,IV	+0.469	.003	4	view →
HNSC	Female	III,IV	−0.536	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TSPO–KIRP

Open the KIRP breakdown →