TSNAX

Across TCGA patient cohorts, TSNAX mutation is significantly associated with the RNA expression of many other genes, with 768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSNAX-associated genes across cancer lineages are KRTAP20-3, TEX36-AS1, and MIR938. Each is linked with TSNAX in more than 1 cancer types. Because this analysis shows association rather than direction, both TSNAX-to-partner and partner-to-TSNAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP20-3 grouped by TSNAX-low versus TSNAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSNAX→partner) and Y-score (partner→TSNAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRTAP20-3 →	+0.066	+4.253	<.001	.004	3	2
UCEC	TEX36-AS1 →	+0.121	+2.092	.004	.005	3	2
SKCM	MIR938 →	+0.516	+5.970	<.001	.002	3	2
SKCM	UBE2V1P9 →	+0.218	+5.097	<.001	.008	3	2
LUAD	MIR4694 →	+0.678	+5.343	<.001	.006	3	2
SKCM	NUDT19P6 →	+0.072	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 768 associations by consensus.

KRTAP20-3 by TSNAX expression — UCEC

Explore this box plot interactively →