TSNAX

Across TCGA pan-cancer cohorts, TSNAX RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSNAX’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSNAX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSNAX is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where TSNAX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSNAX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.570	<.001	12	view →
KICH	Female	II,III,IV	−1.772	<.001	9	view →
LIHC	Male	II,III,IV	+1.308	<.001	9	view →
BRCA	All	III,IV	+0.651	<.001	6	view →
KIRC	Male	All	−0.341	<.001	6	view →
CHOL	Male	All	+2.038	<.001	5	view →
LUAD	Male	All	+0.571	<.001	5	view →
THCA	All	All	−0.251	<.001	5	view →
STAD	All	All	+0.463	.006	3	view →
KIRP	Male	All	−0.468	.001	2	view →
LUSC	All	III,IV	−0.473	.039	1	view →
ESCA	All	All	+0.412	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSNAX–HNSC

Open the HNSC breakdown →