TSNAX-DISC1

Across TCGA pan-cancer cohorts, TSNAX-DISC1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TSNAX-DISC1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSNAX-DISC1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TSNAX-DISC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, COAD, and KICH are the cancer types where TSNAX-DISC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.567	0.283	<.001	98	view →
COAD	DFS	Median	II,III,IV	0.624	0.804	.001	39	view →
KICH	DFS	Quartile	III,IV	0.047	0.871	<.001	29	view →
UVM	OS	Quartile	III,IV	0.407	0.755	.036	27	view →
STAD	DFS	Quartile	All	0.220	0.462	.014	21	view →
ESCA	OS	Quartile	All	0.562	0.759	.025	15	view →
LUSC	DFS	Quartile	II,III,IV	0.233	0.522	.009	13	view →
UCS	DFS	Tertile	IV	0.996	0.689	.049	12	view →
PAAD	DFS	Quartile	II,III,IV	0.222	0.351	.037	5	view →
THYM	OS	Median	II,III,IV	0.677	0.952	.013	4	view →
LAML	DFS	Quartile	All	0.563	0.263	.040	4	view →
LIHC	DFS	Quartile	All	0.400	0.561	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TSNAX-DISC1–HNSC (OS)

Open the HNSC breakdown →