TSNAX-DISC1

Across TCGA pan-cancer cohorts, TSNAX-DISC1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TSNAX-DISC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TSNAX-DISC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSNAX-DISC1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where TSNAX-DISC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSNAX-DISC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.015	<.001	9	view →
KIRP	Female	II,III,IV	+0.034	<.001	6	view →
LUAD	All	All	+0.021	.001	6	view →
BLCA	All	All	+0.049	.015	4	view →
CHOL	All	All	+0.040	.001	2	view →
LUSC	Male	All	+0.023	.008	2	view →
COAD	Male	All	+0.021	.035	1	view →
THCA	Male	All	−0.018	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TSNAX-DISC1–KIRC

Open the KIRC breakdown →