Across TCGA patient cohorts, TSN mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSN-associated genes across cancer lineages are RNU6-225P, GTSE1-DT, and DNM1P28. Each is linked with TSN in more than 1 cancer types. Because this analysis shows association rather than direction, both TSN-to-partner and partner-to-TSN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSN→partner) and Y-score (partner→TSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-225P →	+0.352	+7.640	<.001	.009	3	1
UCEC	GTSE1-DT →	+0.576	+2.818	<.001	.001	3	1
SKCM	DNM1P28 →	+0.101	+5.224	<.001	.007	3	1
UCEC	APOL1 →	-1.285	-3.896	.001	<.001	3	1
UCEC	SLC52A3 →	-1.271	-3.443	<.001	.005	3	1
UCEC	TFPI2 →	+1.454	+3.354	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

Exploration

TSN survival (RNA) · tumor vs normal (RNA) · all TSN data types