TSLP

Across TCGA patient cohorts, TSLP mutation is significantly associated with the RNA expression of many other genes, with 1,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSLP-associated genes across cancer lineages are CHAF1B, SLC35A4, and DLEC1P1. Each is linked with TSLP in more than 1 cancer types. Because this analysis shows association rather than direction, both TSLP-to-partner and partner-to-TSLP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1B grouped by TSLP-low versus TSLP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSLP→partner) and Y-score (partner→TSLP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1B →	+0.628	+2.662	<.001	<.001	3	2
UCEC	SLC35A4 →	+0.376	+3.808	<.001	<.001	3	2
BLCA	DLEC1P1 →	+0.091	+4.836	<.001	.001	3	2
UCEC	SNORA10B →	+0.236	+2.616	<.001	<.001	3	2
UCEC	IGLJ5 →	+0.331	+2.767	<.001	.003	3	2
COAD	TXNL4AP1 →	+0.248	+3.951	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,529 associations by consensus.

CHAF1B by TSLP expression — UCEC

Explore this box plot interactively →