TSLP

Across TCGA pan-cancer cohorts, TSLP RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TSLP data layer compared with 3 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TSLP RNA is associated with better overall survival. In most high-consensus cancer types, elevated TSLP expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUSC show a favorable association.

BRCA, UVM, and SCLC are the cancer types where TSLP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.678	0.559	<.001	73	view →
UVM	OS	Median	III,IV	0.313	0.840	<.001	39	view →
SCLC	OS	Tertile	IV	0.137	0.548	.004	36	view →
LUSC	OS	Quartile	II,III,IV	0.892	0.667	.002	35	view →
LAML	DFS	Median	All	0.441	0.708	.007	26	view →
THYM	OS	Median	II,III,IV	1.000	0.671	<.001	24	view →
KIRP	DFS	Tertile	All	0.947	0.836	.002	18	view →
GBM	DFS	Quartile	All	0.126	0.406	.003	18	view →
ACC	OS	Median	III,IV	0.321	0.789	.011	14	view →
LIHC	OS	Tertile	III,IV	0.605	0.270	.010	13	view →
LUAD	DFS	Quartile	All	0.901	0.748	.001	10	view →
READ	OS	Quartile	IV	0.416	0.878	.031	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TSLP–BRCA (OS)

Open the BRCA breakdown →