TSKU

Across TCGA patient cohorts, TSKU mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSKU-associated genes across cancer lineages are Gab2, ACC1, and INPP4B. Each is linked with TSKU in more than 1 cancer types. Because this analysis shows association rather than direction, both TSKU-to-partner and partner-to-TSKU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TSKU-low versus TSKU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSKU→partner) and Y-score (partner→TSKU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.328	+3.169	.012	.018	3	2
UCEC	ACC1 →	+0.417	+2.128	.001	.009	3	2
UCEC	INPP4B →	-0.274	-2.700	.021	.005	3	2
UCEC	14-3-3_beta →	-0.108	-2.195	.003	.009	3	1
UCEC	EGFR →	-0.164	-3.143	.005	.018	3	1
UCEC	eIF4E →	+0.186	+1.847	.016	.008	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Gab2 by TSKU expression — UCEC

Explore this box plot interactively →