TSKU

Across TCGA cell cohorts, TSKU mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSKU-associated genes across cancer lineages are SEMG2, CCDC42, and UCMA. Each is linked with TSKU in more than 1 cancer types. Because this analysis shows association rather than direction, both TSKU-to-partner and partner-to-TSKU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by TSKU-low versus TSKU-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSKU→partner) and Y-score (partner→TSKU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG2 →	+0.379	+2.878	.008	.009	3	1
LARGE_INTESTINE	CCDC42 →	+0.035	+2.925	<.001	.007	3	1
LARGE_INTESTINE	UCMA →	+0.015	+3.217	<.001	.006	3	1
LARGE_INTESTINE	CCDC197 →	+0.021	+3.115	<.001	.004	3	1
LARGE_INTESTINE	OR2D3 →	+0.022	+2.925	<.001	.007	3	1
LARGE_INTESTINE	HTR3D →	+0.011	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SEMG2 by TSKU expression — LARGE_INTESTINE

Explore this box plot interactively →