TSIX

Across TCGA patient cohorts, TSIX mutation is significantly associated with the RNA expression of many other genes, with 6,419 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSIX-associated genes across cancer lineages are MCM7, NF1P11, and LINC02485. Each is linked with TSIX in more than 3 cancer types. Because this analysis shows association rather than direction, both TSIX-to-partner and partner-to-TSIX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM7 grouped by TSIX-low versus TSIX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSIX→partner) and Y-score (partner→TSIX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM7 →	+0.465	+1.815	<.001	<.001	3	4
BRCA	NF1P11 →	+0.128	+5.020	<.001	.009	3	3
CESC	LINC02485 →	+0.068	+2.041	<.001	.007	3	3
CESC	NF1P10 →	+0.102	+3.569	<.001	.002	3	3
UCEC	DNAJA1 →	+0.501	+1.547	<.001	<.001	3	3
UCEC	HDGFL2 →	+0.452	+1.862	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,419 associations by consensus.

MCM7 by TSIX expression — UCEC

Explore this box plot interactively →