TSIX

Across TCGA pan-cancer cohorts, TSIX RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TSIX’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSIX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSIX is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where TSIX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSIX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.007	.010	7	view →
THCA	Female	II,III,IV	−0.067	<.001	5	view →
KICH	Female	All	−0.025	<.001	5	view →
BRCA	Female	All	+0.040	.008	4	view →
BLCA	Male	All	+0.008	.010	3	view →
COAD	Male	All	+0.004	.014	2	view →
KIRC	Female	All	+0.014	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TSIX–HNSC

Open the HNSC breakdown →