TSHR

Across TCGA patient cohorts, TSHR mutation is significantly associated with the RNA expression of many other genes, with 5,554 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHR-associated genes across cancer lineages are ATPAF2, NDUFA6, and RCC1. Each is linked with TSHR in more than 3 cancer types. Because this analysis shows association rather than direction, both TSHR-to-partner and partner-to-TSHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATPAF2 grouped by TSHR-low versus TSHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHR→partner) and Y-score (partner→TSHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATPAF2 →	+0.416	+2.055	<.001	<.001	3	4
COAD	NDUFA6 →	+0.572	+3.362	<.001	.004	3	4
UCEC	RCC1 →	+0.496	+1.840	<.001	<.001	3	4
UCEC	SKA1 →	+0.743	+2.555	<.001	<.001	3	4
UCEC	HPGDS →	-0.315	-2.087	.002	.005	3	4
COAD	POC1A →	+0.649	+3.200	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,554 associations by consensus.

ATPAF2 by TSHR expression — UCEC

Explore this box plot interactively →