TSHR

Across TCGA pan-cancer cohorts, TSHR RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TSHR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TSHR RNA is repressed in tumor relative to normal tissue. In most cancer types TSHR is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where TSHR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSHR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.163	<.001	10	view →
KIRC	Male	All	+0.393	<.001	9	view →
LUAD	Male	All	+0.412	<.001	8	view →
COAD	Female	III,IV	−0.278	<.001	8	view →
UCEC	All	III,IV	−0.422	.015	6	view →
BRCA	All	III,IV	−0.358	<.001	6	view →
LUSC	All	All	+0.225	<.001	5	view →
KICH	All	All	−0.162	<.001	4	view →
STAD	Female	All	+0.235	.044	2	view →
READ	Female	All	−0.130	.027	2	view →
CHOL	All	II,III,IV	+0.055	.038	2	view →
STAD	Male	IV	−0.390	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

TSHR–THCA

Open the THCA breakdown →