TSHB

Across TCGA patient cohorts, TSHB protein abundance is significantly associated with the RNA expression of many other genes, with 285 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TSHB-associated genes across cancer lineages are LGALS2, MTG2, and TCFL5. Each is linked with TSHB in more than 1 cancer types. Because this analysis shows association rather than direction, both TSHB-to-partner and partner-to-TSHB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSHB versus LGALS2 in PDAC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHB→partner) and Y-score (partner→TSHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LGALS2 →	+1.328	+0.556	.007	.001	3	1
PDAC	MTG2 →	-0.368	-0.417	.003	.003	3	1
PDAC	TCFL5 →	-0.492	-0.475	<.001	<.001	3	1
PDAC	DIDO1 →	-0.349	-0.437	.005	.002	3	1
PDAC	GID8 →	-0.444	-0.761	<.001	.001	3	1
PDAC	ACOT8 →	-0.334	-0.440	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 285 associations by consensus.

TSHB vs LGALS2 — PDAC

Explore this scatter interactively →