TSHB

Across TCGA pan-cancer cohorts, TSHB RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TSHB data layer compared with 3 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher TSHB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TSHB expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

THCA, PAAD, and ESCA are the cancer types where TSHB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	II,III,IV	0.670	0.932	<.001	75	view →
PAAD	DFS	Quartile	All	0.635	0.408	.003	39	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
CESC	DFS	Tertile	IV	0.224	0.555	.036	36	view →
ACC	DFS	Tertile	II,III,IV	0.046	0.732	<.001	36	view →
KIRC	DFS	Tertile	III,IV	0.734	0.466	.007	32	view →
STAD	OS	Tertile	IV	0.497	0.250	.015	24	view →
UCEC	DFS	Tertile	All	0.828	0.909	.006	24	view →
KIRP	DFS	Tertile	II,III,IV	0.112	0.547	.021	21	view →
LUSC	OS	Tertile	III,IV	0.671	0.285	.016	18	view →
DLBC	DFS	Tertile	III,IV	0.137	0.761	.014	18	view →
BRCA	DFS	Median	III,IV	0.858	0.730	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TSHB–THCA (OS)

Open the THCA breakdown →