TSHB

Across TCGA pan-cancer cohorts, TSHB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSHB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TSHB RNA is repressed in tumor relative to normal tissue. In most cancer types TSHB is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRP are the cancer types where TSHB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSHB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.104	<.001	11	view →
THCA	All	II,III,IV	−0.154	<.001	10	view →
KIRP	Male	All	−0.290	<.001	9	view →
COAD	All	II,III,IV	−0.236	<.001	8	view →
KIRC	All	All	−0.186	<.001	8	view →
KICH	All	All	−0.305	<.001	7	view →
UCEC	All	All	−0.906	<.001	6	view →
LUSC	Male	II,III,IV	−0.376	<.001	6	view →
BRCA	All	All	−0.255	<.001	6	view →
READ	Female	All	−0.632	.002	4	view →
LUAD	All	All	−0.162	.002	2	view →
STAD	Male	All	−0.230	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSHB–BLCA

Open the BLCA breakdown →