TSHB

Across TCGA patient cohorts, TSHB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSHB-associated genes across cancer lineages are Fibronectin, ACVRL1, and p62 Lck ligand. Each is linked with TSHB in more than 1 cancer types. Because this analysis shows association rather than direction, both TSHB-to-partner and partner-to-TSHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by TSHB-low versus TSHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHB→partner) and Y-score (partner→TSHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.369	-2.584	.016	.011	3	1
UCEC	ACVRL1 →	-0.232	-3.156	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.350	+3.179	.021	.010	3	1
UCEC	S6_pS235_S236 →	+0.559	+3.321	.005	.010	3	1
UCEC	Tuberin →	+0.315	+2.331	.012	.019	3	1
UCEC	c-Kit →	-0.220	-3.700	.043	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Fibronectin by TSHB expression — UCEC

Explore this box plot interactively →