TSHB

Across TCGA cell cohorts, TSHB RNA expression is significantly associated with the go_rna of many other GO terms, with 215 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSHB-associated GO terms across cancer lineages are Delamination, Epithelial cell fate commitment, and Negative regulation of cholesterol metabolic process. Each is linked with TSHB in more than 1 cancer types. Because this analysis shows association rather than direction, both TSHB-to-partner and partner-to-TSHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Delamination grouped by TSHB-low versus TSHB-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSHB→partner) and Y-score (partner→TSHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Delamination →	-0.137	-0.021	.005	.004	3	2
CNS	Epithelial cell fate commitment →	-0.153	-0.028	.003	.007	3	2
LUNG_NSCLC_LUAD	Negative regulation of cholesterol metabolic process →	+0.187	+0.037	<.001	.008	3	2
CNS	piRNA-mediated heterochromatin formation →	-0.219	-0.021	.004	.005	3	2
BLOOD_Leukemia	Regulation of mitotic sister chromatid separation →	+0.087	+0.045	<.001	.009	3	2
BLOOD_Leukemia	Mitotic nuclear division →	+0.056	+0.065	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 215 associations by consensus.

Delamination by TSHB expression — CNS

Explore this box plot interactively →