TSC2

Across TCGA cell cohorts, TSC2 RNA expression is significantly associated with the RNA expression of many other genes, with 12,447 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSC2-associated genes across cancer lineages are PKD1, CIAO3, and MAPK8IP3. Each is linked with TSC2 in more than 18 cancer types. Because this analysis shows association rather than direction, both TSC2-to-partner and partner-to-TSC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSC2 versus PKD1 in BONE, with a Pearson correlation of 0.87.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSC2→partner) and Y-score (partner→TSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PKD1 →	+2.041	+1.166	<.001	<.001	3	19
BLOOD_Leukemia	CIAO3 →	+1.132	+0.696	<.001	<.001	3	19
BONE	MAPK8IP3 →	+1.941	+1.223	<.001	<.001	3	19
BONE	E4F1 →	+1.258	+1.163	<.001	<.001	3	19
URINARY_TRACT	ANKS3 →	+1.493	+1.447	<.001	<.001	3	19
URINARY_TRACT	HECTD4 →	+1.365	+1.507	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,447 associations by consensus.

TSC2 vs PKD1 — BONE

Explore this scatter interactively →