TSC2

Across TCGA pan-cancer cohorts, TSC2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TSC2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSC2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TSC2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

HNSC, ACC, and MESO are the cancer types where TSC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.468	0.221	<.001	83	view →
ACC	DFS	Median	All	0.549	0.900	.001	50	view →
MESO	OS	Quartile	III,IV	0.527	0.723	.014	33	view →
READ	OS	Median	All	0.966	0.413	.001	29	view →
UVM	DFS	Median	III,IV	0.621	0.273	.012	21	view →
LIHC	DFS	Tertile	All	0.436	0.611	<.001	20	view →
BRCA	DFS	Median	III,IV	0.924	0.831	.006	13	view →
LUSC	DFS	Tertile	III,IV	0.507	1.000	.011	12	view →
BLCA	DFS	Median	IV	0.128	0.304	.008	12	view →
PAAD	DFS	Quartile	All	0.436	0.204	.023	10	view →
GBM	DFS	Tertile	All	0.424	0.184	.004	9	view →
SARC	OS	Tertile	All	0.462	0.805	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TSC2–HNSC (DFS)

Open the HNSC breakdown →