TRUB1

Across TCGA patient cohorts, TRUB1 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRUB1-associated genes across cancer lineages are OR11H12, RNA5SP447, and NF1P6. Each is linked with TRUB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRUB1-to-partner and partner-to-TRUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H12 grouped by TRUB1-low versus TRUB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRUB1→partner) and Y-score (partner→TRUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR11H12 →	+0.045	+4.614	<.001	.006	3	3
CESC	RNA5SP447 →	+0.349	+5.201	.004	.007	3	2
CESC	NF1P6 →	+0.079	+6.342	.005	.001	3	2
CESC	LINC02559 →	+1.376	+6.342	<.001	.001	3	2
LUAD	MTND1P28 →	+0.045	+4.554	<.001	.009	3	2
LUAD	VENTXP8 →	+0.498	+4.554	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

OR11H12 by TRUB1 expression — SKCM

Explore this box plot interactively →