TRUB1

Across TCGA patient cohorts, TRUB1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TRUB1-associated genes across cancer lineages are Monocytes, CD4+ Tcm, and CD4+ Tem. Each is linked with TRUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRUB1-to-partner and partner-to-TRUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by TRUB1-low versus TRUB1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRUB1→partner) and Y-score (partner→TRUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Monocytes →	+0.028	+3.935	.006	.036	3	2
SKCM	CD4+ Tcm →	+0.016	+4.385	<.001	.008	3	1
STAD	CD4+ Tem →	+0.020	+4.450	.001	.019	3	1
STAD	CD8+ Tem →	+0.014	+5.567	<.001	.004	3	1
STAD	NK cells →	+0.010	+6.597	<.001	.001	3	1
UCEC	Mesangial cells →	-0.060	-3.305	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Monocytes by TRUB1 expression — STAD

Explore this box plot interactively →