TRUB1

Across TCGA cell cohorts, TRUB1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TRUB1-associated genes across cancer lineages are MTNR1B, SIGLEC7, and IDI2. Each is linked with TRUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRUB1-to-partner and partner-to-TRUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTNR1B grouped by TRUB1-low versus TRUB1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRUB1→partner) and Y-score (partner→TRUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MTNR1B →	+0.139	+4.906	<.001	.006	3	1
OESOPHAGUS	SIGLEC7 →	+0.063	+4.906	<.001	.006	3	1
OVARY	IDI2 →	+0.021	+4.029	.001	.009	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	HSF5 →	+0.006	+4.029	<.001	.009	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MTNR1B by TRUB1 expression — OESOPHAGUS

Explore this box plot interactively →