TRPV4

Across TCGA patient cohorts, TRPV4 mutation is significantly associated with the RNA expression of many other genes, with 4,815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPV4-associated genes across cancer lineages are OR4F17, ACTR5, and CORO2B. Each is linked with TRPV4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPV4-to-partner and partner-to-TRPV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F17 grouped by TRPV4-low versus TRPV4-high in PAAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV4→partner) and Y-score (partner→TRPV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	OR4F17 →	+0.038	+6.426	<.001	.001	3	3
UCEC	ACTR5 →	+0.211	+2.086	.009	<.001	3	3
UCEC	CORO2B →	-0.478	-2.874	.001	<.001	3	3
UCEC	OIP5 →	+0.699	+2.643	<.001	<.001	3	3
UCEC	KAT2B →	+0.524	+1.702	<.001	<.001	3	3
UCEC	ZWINT →	+0.695	+2.263	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,815 associations by consensus.

OR4F17 by TRPV4 expression — PAAD

Explore this box plot interactively →