TRPV4

Across TCGA pan-cancer cohorts, TRPV4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TRPV4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRPV4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRPV4 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

COAD, KIRP, and LUSC are the cancer types where TRPV4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPV4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+1.214	<.001	11	view →
KIRP	All	III,IV	−2.101	<.001	9	view →
LUSC	Male	All	+1.876	<.001	9	view →
READ	All	II,III,IV	+1.457	.004	6	view →
KICH	All	All	−1.049	<.001	6	view →
LIHC	Male	All	−1.388	<.001	5	view →
UCEC	All	All	+1.081	.009	4	view →
BRCA	Female	II,III,IV	−0.451	.002	4	view →
CHOL	Male	All	+2.143	.003	2	view →
PRAD	All	All	−0.518	.005	2	view →
STAD	All	All	+0.798	.034	1	view →
THCA	Female	III,IV	+0.438	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TRPV4–COAD

Open the COAD breakdown →