TRPV4

Across TCGA pan-cancer cohorts, TRPV4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRPV4 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRPV4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRPV4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, UVM, and KIRP are the cancer types where TRPV4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.740	0.579	<.001	113	view →
UVM	OS	Tertile	II,III,IV	0.385	0.797	<.001	99	view →
KIRP	OS	Tertile	II,III,IV	0.868	0.587	.002	79	view →
OV	OS	Tertile	All	0.295	0.421	.001	64	view →
KIRC	DFS	Tertile	All	0.726	0.520	<.001	64	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.437	.007	34	view →
LGG	DFS	Quartile	All	0.749	0.881	<.001	28	view →
BLCA	DFS	Quartile	II,III,IV	0.552	0.410	.011	19	view →
CHOL	OS	Median	All	1.000	0.195	.002	18	view →
STAD	OS	Quartile	All	0.479	0.799	.009	13	view →
ESCA	OS	Median	All	1.000	0.659	.020	13	view →
UCEC	DFS	Median	All	0.719	0.581	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRPV4–HNSC (DFS)

Open the HNSC breakdown →