TRPV4

Across TCGA patient cohorts, TRPV4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPV4-associated genes across cancer lineages are eIF4E, Ku80, and PCNA. Each is linked with TRPV4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPV4-to-partner and partner-to-TRPV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TRPV4-low versus TRPV4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV4→partner) and Y-score (partner→TRPV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.164	+1.485	.007	.003	3	2
UCEC	Ku80 →	+0.189	+1.375	.006	.020	3	2
UCEC	PCNA →	+0.173	+1.485	.005	.003	3	2
UCEC	PDCD4 →	-0.321	-1.999	.019	.008	3	2
UCEC	STAT3_pY705 →	-0.276	-1.642	<.001	.005	3	2
UCEC	TIGAR →	+0.099	+1.714	.026	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eIF4E by TRPV4 expression — UCEC

Explore this box plot interactively →