TRPV4

Across TCGA cell cohorts, TRPV4 mutation is significantly associated with the RNA expression of many other genes, with 861 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPV4-associated genes across cancer lineages are TNRC6B, GSR, and QRSL1. Each is linked with TRPV4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPV4-to-partner and partner-to-TRPV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6B grouped by TRPV4-low versus TRPV4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPV4→partner) and Y-score (partner→TRPV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNRC6B →	+0.711	+3.523	<.001	<.001	3	2
LARGE_INTESTINE	GSR →	+0.679	+3.389	.007	.001	3	2
LARGE_INTESTINE	QRSL1 →	+0.580	+2.743	<.001	.001	3	2
LARGE_INTESTINE	MED9 →	+0.482	+2.829	<.001	<.001	3	2
LARGE_INTESTINE	SMARCA5 →	+0.606	+2.743	<.001	.001	3	2
LARGE_INTESTINE	RAB33B →	+0.662	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 861 associations by consensus.

TNRC6B by TRPV4 expression — LARGE_INTESTINE

Explore this box plot interactively →