TRPS1

Across TCGA cell cohorts, TRPS1 mutation is significantly associated with the RNA expression of many other genes, with 1,748 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPS1-associated genes across cancer lineages are OR52B2, SERPINB11, and NDUFAF4. Each is linked with TRPS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPS1-to-partner and partner-to-TRPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52B2 grouped by TRPS1-low versus TRPS1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPS1→partner) and Y-score (partner→TRPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR52B2 →	+0.024	+3.544	<.001	.001	3	3
STOMACH	SERPINB11 →	+0.038	+3.152	<.001	.002	3	2
BLOOD_Leukemia	NDUFAF4 →	+0.685	+3.351	.003	.003	2	3
LARGE_INTESTINE	ZIC5 →	+1.060	+2.265	<.001	.001	3	2
BLOOD_Leukemia	NKX2-6 →	+0.197	+2.786	<.001	.009	3	2
LARGE_INTESTINE	GNPNAT1 →	+0.728	+4.129	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,748 associations by consensus.

OR52B2 by TRPS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →