TRPS1

Across TCGA pan-cancer cohorts, TRPS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRPS1 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRPS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRPS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where TRPS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.716	0.557	<.001	102	view →
UVM	DFS	Quartile	III,IV	0.216	0.750	.004	52	view →
SKCM	OS	Median	III,IV	0.485	0.296	.001	49	view →
BLCA	OS	Tertile	II,III,IV	0.535	0.681	.002	47	view →
PAAD	DFS	Tertile	All	0.152	0.397	.005	28	view →
STAD	DFS	Quartile	IV	0.123	0.632	.006	23	view →
KIRC	DFS	Quartile	All	0.919	0.750	.007	16	view →
ESCA	DFS	Tertile	III,IV	0.517	0.301	.008	16	view →
LGG	OS	Median	All	0.390	0.515	.013	14	view →
KIRP	DFS	Tertile	All	0.802	0.906	.022	12	view →
SARC	DFS	Quartile	All	0.237	0.529	.003	12	view →
CHOL	DFS	Median	All	0.606	0.237	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRPS1–HNSC (DFS)

Open the HNSC breakdown →