TRPM5

Across TCGA patient cohorts, TRPM5 mutation is significantly associated with the RNA expression of many other genes, with 4,776 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRPM5-associated genes across cancer lineages are RNU6-642P, CENPU, and TEDC2. Each is linked with TRPM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPM5-to-partner and partner-to-TRPM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-642P grouped by TRPM5-low versus TRPM5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM5→partner) and Y-score (partner→TRPM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-642P →	+0.428	+4.503	.002	.005	3	3
UCEC	CENPU →	+0.803	+2.305	<.001	<.001	3	3
SKCM	TEDC2 →	+0.556	+2.906	<.001	<.001	3	3
SKCM	DTYMK →	+0.618	+3.845	<.001	<.001	3	3
SKCM	HLTF →	+0.790	+3.725	<.001	<.001	3	3
UCEC	DIS3 →	+0.375	+2.608	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,776 associations by consensus.

RNU6-642P by TRPM5 expression — CESC

Explore this box plot interactively →