TRPM5

Across TCGA pan-cancer cohorts, TRPM5 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRPM5 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TRPM5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRPM5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THYM show a favorable association.

KIRP, COAD, and UCEC are the cancer types where TRPM5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.358	0.817	<.001	72	view →
COAD	OS	Tertile	All	0.805	0.915	.002	57	view →
UCEC	DFS	Median	All	0.557	0.719	<.001	52	view →
ACC	DFS	Quartile	All	0.156	0.732	.006	22	view →
LGG	DFS	Tertile	All	0.666	0.799	.003	20	view →
SKCM	DFS	Median	All	0.284	0.159	<.001	17	view →
PCPG	DFS	Quartile	All	0.792	0.973	.002	15	view →
GBM	OS	Tertile	All	0.215	0.351	.031	12	view →
PRAD	DFS	Tertile	All	0.701	0.780	.009	12	view →
THYM	DFS	Median	III,IV	1.000	0.508	.013	8	view →
BLCA	OS	Tertile	II,III,IV	0.669	0.543	.025	7	view →
THCA	OS	Quartile	II,III,IV	0.955	1.000	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRPM5–KIRP (DFS)

Open the KIRP breakdown →