TRPM4

Across TCGA patient cohorts, TRPM4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM4-associated genes across cancer lineages are ATM, c-Kit, and eEF2. Each is linked with TRPM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPM4-to-partner and partner-to-TRPM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRPM4-low versus TRPM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM4→partner) and Y-score (partner→TRPM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.393	-2.102	.006	.016	3	3
UCEC	c-Kit →	-0.201	-1.745	.007	.013	3	3
COAD	eEF2 →	+0.459	+3.000	.001	.035	3	2
COAD	GAPDH →	+0.537	+3.178	.031	.010	3	2
COAD	GSK3-a-b →	+0.216	+2.857	.003	.032	3	2
COAD	Caspase-7-cleavedD198 →	+1.668	+3.178	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ATM by TRPM4 expression — UCEC

Explore this box plot interactively →