TRPM4

Across TCGA pan-cancer cohorts, TRPM4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRPM4 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TRPM4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRPM4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

UVM, HNSC, and UCEC are the cancer types where TRPM4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.274	0.759	<.001	116	view →
HNSC	DFS	Tertile	All	0.794	0.647	<.001	86	view →
UCEC	OS	Median	All	0.793	0.565	<.001	84	view →
ACC	DFS	Tertile	All	0.359	0.805	<.001	75	view →
LGG	OS	Median	All	0.730	0.885	<.001	51	view →
THCA	DFS	Quartile	II,III,IV	0.401	0.796	.002	35	view →
KIRC	DFS	Median	III,IV	0.669	0.816	.002	32	view →
MESO	OS	Median	II,III,IV	0.324	0.721	.010	31	view →
SCLC	OS	Quartile	III,IV	0.160	0.523	.011	30	view →
KIRP	DFS	Median	II,III,IV	0.812	0.544	.009	28	view →
BRCA	OS	Median	IV	0.810	0.352	.006	24	view →
ESCA	DFS	Quartile	II,III,IV	0.109	1.000	.020	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRPM4–UVM (DFS)

Open the UVM breakdown →