TRPM4

Across TCGA pan-cancer cohorts, TRPM4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TRPM4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRPM4 RNA is repressed in tumor relative to normal tissue. In most cancer types TRPM4 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where TRPM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.136	<.001	12	view →
HNSC	Female	All	+0.747	<.001	10	view →
LIHC	All	III,IV	+1.006	<.001	9	view →
COAD	Female	II,III,IV	−0.994	<.001	7	view →
THCA	All	II,III,IV	−0.296	.003	7	view →
STAD	All	All	+1.044	<.001	6	view →
BRCA	All	All	+0.489	<.001	6	view →
CHOL	Male	All	+2.816	<.001	5	view →
UCEC	All	All	+1.268	<.001	4	view →
READ	All	All	−0.977	.009	4	view →
PRAD	All	All	+1.714	<.001	2	view →
PAAD	All	All	+1.614	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TRPM4–KIRC

Open the KIRC breakdown →