TRPM4

Across TCGA cell cohorts, TRPM4 mutation is significantly associated with the RNA expression of many other genes, with 941 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM4-associated genes across cancer lineages are USP29, PPIAL4D, and IFNA5. Each is linked with TRPM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPM4-to-partner and partner-to-TRPM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by TRPM4-low versus TRPM4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM4→partner) and Y-score (partner→TRPM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP29 →	+0.009	+4.078	<.001	.009	3	3
OESOPHAGUS	PPIAL4D →	+0.093	+4.017	.004	.007	3	2
LUNG_SCLC	IFNA5 →	+0.043	+3.624	<.001	.005	3	2
BREAST	ZNF705G →	+0.006	+5.169	<.001	.005	3	2
BLOOD_Leukemia	MAEL →	+0.369	+3.601	<.001	.002	3	2
BLOOD_Leukemia	IQCF5 →	+0.052	+3.201	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 941 associations by consensus.

USP29 by TRPM4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →