TRPM3

Across TCGA patient cohorts, TRPM3 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM3-associated genes across cancer lineages are eEF2, ERK2, and Di-Ras3. Each is linked with TRPM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRPM3-to-partner and partner-to-TRPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TRPM3-low versus TRPM3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM3→partner) and Y-score (partner→TRPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	eEF2 →	+0.222	+3.169	.033	.018	3	4
BLCA	ERK2 →	+0.178	+1.891	.013	.030	3	4
BRCA	Di-Ras3 →	-0.266	-2.993	.028	.038	3	4
COAD	Caspase-7-cleavedD198 →	+0.817	+2.824	.006	.034	3	4
UCEC	C-Raf →	+0.109	+1.206	.001	.007	3	4
STAD	FoxM1 →	+0.236	+2.490	.015	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

eEF2 by TRPM3 expression — BLCA

Explore this box plot interactively →