TRPM3

Across TCGA cell cohorts, TRPM3 mutation is significantly associated with the RNA expression of many other genes, with 2,290 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPM3-associated genes across cancer lineages are PIP, LCE2A, and HPS4. Each is linked with TRPM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPM3-to-partner and partner-to-TRPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by TRPM3-low versus TRPM3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM3→partner) and Y-score (partner→TRPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PIP →	+0.102	+3.584	.001	.008	3	2
OESOPHAGUS	LCE2A →	+0.089	+3.392	<.001	.007	3	2
LARGE_INTESTINE	HPS4 →	+0.570	+2.216	<.001	<.001	3	2
LARGE_INTESTINE	ANKRD54 →	+0.582	+2.216	<.001	<.001	3	2
LARGE_INTESTINE	POLDIP3 →	+0.682	+2.130	<.001	<.001	3	2
LARGE_INTESTINE	LMF2 →	+0.633	+3.321	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,290 associations by consensus.

PIP by TRPM3 expression — OESOPHAGUS

Explore this box plot interactively →