TRPC4AP

Across TCGA patient cohorts, TRPC4AP mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC4AP-associated genes across cancer lineages are ATM, Cyclin-B1, and PKC-a_pS657. Each is linked with TRPC4AP in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC4AP-to-partner and partner-to-TRPC4AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRPC4AP-low versus TRPC4AP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC4AP→partner) and Y-score (partner→TRPC4AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.428	-1.836	.002	.001	3	2
UCEC	Cyclin-B1 →	+0.624	+2.247	<.001	.001	3	2
LUSC	PKC-a_pS657 →	+0.302	+2.816	.008	.036	3	1
UCEC	EGFR_pY1068 →	-0.266	-2.115	<.001	<.001	3	1
UCEC	EGFR →	-0.130	-1.807	.009	.025	3	1
UCEC	Gab2 →	+0.321	+1.353	.004	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by TRPC4AP expression — UCEC

Explore this box plot interactively →