TRPC4AP

Across TCGA pan-cancer cohorts, TRPC4AP RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TRPC4AP data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TRPC4AP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRPC4AP expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

LIHC, KICH, and UVM are the cancer types where TRPC4AP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.611	0.762	<.001	86	view →
KICH	DFS	Median	III,IV	0.240	1.000	.001	65	view →
UVM	DFS	Median	All	0.426	0.756	<.001	50	view →
LUSC	DFS	Median	III,IV	0.180	0.835	.001	36	view →
KIRC	DFS	Median	IV	0.233	0.492	.006	36	view →
ACC	DFS	Tertile	All	0.402	0.759	.001	29	view →
READ	DFS	Median	III,IV	0.848	0.630	.006	27	view →
LGG	OS	Quartile	All	0.487	0.790	<.001	23	view →
UCS	DFS	Median	IV	0.885	0.440	.015	18	view →
OV	OS	Tertile	All	0.804	0.877	.004	18	view →
PAAD	OS	Quartile	II,III,IV	0.415	0.729	.013	16	view →
COAD	OS	Quartile	IV	0.952	0.532	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TRPC4AP–LIHC (OS)

Open the LIHC breakdown →