TRPC4AP

Across TCGA pan-cancer cohorts, TRPC4AP RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TRPC4AP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRPC4AP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRPC4AP is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where TRPC4AP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPC4AP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.711	<.001	12	view →
COAD	Male	II,III,IV	+0.921	<.001	11	view →
LIHC	Female	II,III,IV	+1.027	<.001	9	view →
BLCA	All	All	+0.524	<.001	9	view →
STAD	Male	II,III,IV	+1.035	<.001	8	view →
LUAD	All	All	+0.263	<.001	8	view →
KIRC	All	All	+0.275	<.001	7	view →
KIRP	All	II,III,IV	+0.568	.005	6	view →
BRCA	All	III,IV	+0.308	<.001	6	view →
CHOL	All	All	+1.717	<.001	5	view →
ESCA	All	All	+0.813	<.001	5	view →
READ	All	All	+0.559	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TRPC4AP–HNSC

Open the HNSC breakdown →