TRPC4AP

Across TCGA cell cohorts, TRPC4AP mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC4AP-associated genes across cancer lineages are GCAT, RBFA, and SH3GL2. Each is linked with TRPC4AP in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC4AP-to-partner and partner-to-TRPC4AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by TRPC4AP-low versus TRPC4AP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC4AP→partner) and Y-score (partner→TRPC4AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.371	+3.212	.001	.006	3	1
LARGE_INTESTINE	RBFA →	+0.724	+3.212	.005	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.480	+3.474	<.001	.003	3	1
LARGE_INTESTINE	TRIM37 →	+0.593	+3.212	.008	.006	3	1
LARGE_INTESTINE	UGDH →	+0.912	+3.299	.003	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.097	+2.378	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

GCAT by TRPC4AP expression — LARGE_INTESTINE

Explore this box plot interactively →