TRPC3

Across TCGA cell cohorts, TRPC3 mutation is significantly associated with the RNA expression of many other genes, with 301 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC3-associated genes across cancer lineages are CSNKA2IP, PROP1, and GPR139. Each is linked with TRPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC3-to-partner and partner-to-TRPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSNKA2IP grouped by TRPC3-low versus TRPC3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC3→partner) and Y-score (partner→TRPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CSNKA2IP →	+0.036	+4.906	<.001	.006	3	2
PANCREAS	PROP1 →	+0.019	+4.786	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	GPR139 →	+0.076	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	ARGFX →	+0.083	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	MFRP →	+0.023	+5.357	<.001	.003	3	2
LARGE_INTESTINE	MAGEB4 →	+0.008	+2.830	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 301 associations by consensus.

CSNKA2IP by TRPC3 expression — OESOPHAGUS

Explore this box plot interactively →