TRPC3

Across TCGA pan-cancer cohorts, TRPC3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TRPC3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRPC3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRPC3 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

HNSC, BLCA, and LUSC are the cancer types where TRPC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRPC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.105	<.001	12	view →
BLCA	Male	All	−1.493	<.001	11	view →
LUSC	Female	II,III,IV	−0.932	<.001	9	view →
KICH	All	All	+1.131	<.001	7	view →
LUAD	Female	III,IV	−0.841	<.001	7	view →
UCEC	All	All	−0.369	<.001	6	view →
BRCA	Female	II,III,IV	+0.101	<.001	4	view →
KIRP	All	All	+0.623	.020	3	view →
THCA	All	II,III,IV	−0.079	.005	3	view →
PRAD	All	All	−0.302	<.001	2	view →
LIHC	Female	II,III,IV	+0.051	.036	1	view →
LIHC	Male	III,IV	−0.036	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

TRPC3–HNSC

Open the HNSC breakdown →