TRMT11

Across TCGA patient cohorts, TRMT11 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT11-associated genes across cancer lineages are TFRC, INPP4B, and JNK_pT183_Y185. Each is linked with TRMT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT11-to-partner and partner-to-TRMT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TRMT11-low versus TRMT11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT11→partner) and Y-score (partner→TRMT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.630	+3.584	.002	.002	3	2
UCEC	INPP4B →	-0.310	-1.986	.014	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.186	-3.169	.004	.018	3	1
UCEC	JNK2 →	+0.214	+2.000	.006	.010	3	1
UCEC	MEK1 →	+0.490	+2.000	<.001	.010	3	1
UCEC	mTOR_pS2448 →	-0.130	-3.308	.026	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TFRC by TRMT11 expression — UCEC

Explore this box plot interactively →