TRMT11

Across TCGA pan-cancer cohorts, TRMT11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRMT11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRMT11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRMT11 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where TRMT11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRMT11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.924	<.001	12	view →
COAD	Male	II,III,IV	+1.015	<.001	10	view →
KICH	Female	II,III,IV	−1.231	<.001	8	view →
STAD	All	II,III,IV	+0.585	.002	6	view →
BRCA	Female	All	−0.274	<.001	6	view →
READ	All	All	+0.641	.007	4	view →
KIRP	All	All	+0.319	.008	4	view →
LUAD	All	All	+0.292	.002	3	view →
ESCA	All	All	+0.806	.013	2	view →
UCEC	All	IV	−0.375	.037	2	view →
CHOL	All	All	+0.718	.013	1	view →
LIHC	Female	III,IV	+0.548	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRMT11–HNSC

Open the HNSC breakdown →