TRMT11

Across TCGA pan-cancer cohorts, TRMT11 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRMT11 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TRMT11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRMT11 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

CESC, SKCM, and HNSC are the cancer types where TRMT11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	IV	0.091	0.596	.003	88	view →
SKCM	OS	Tertile	II,III,IV	0.443	0.266	<.001	59	view →
HNSC	OS	Tertile	All	0.446	0.727	.001	38	view →
KIRC	DFS	Median	IV	0.224	0.431	.003	28	view →
SCLC	OS	Tertile	All	0.604	0.823	.006	23	view →
KICH	OS	Median	II,III,IV	0.639	0.959	.004	21	view →
LGG	DFS	Median	All	0.456	0.343	.004	21	view →
UCEC	DFS	Tertile	All	0.782	0.881	.003	20	view →
LIHC	DFS	Tertile	III,IV	0.243	0.492	.014	19	view →
ACC	OS	Median	IV	0.777	0.309	.019	13	view →
MESO	OS	Median	IV	0.337	0.818	.006	12	view →
UVM	OS	Median	All	0.797	1.000	.028	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRMT11–CESC (OS)

Open the CESC breakdown →