TRMO

Across TCGA cell cohorts, TRMO mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRMO-associated genes across cancer lineages are SCYGR10, OR1A1, and LCE2A. Each is linked with TRMO in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMO-to-partner and partner-to-TRMO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCYGR10 grouped by TRMO-low versus TRMO-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMO→partner) and Y-score (partner→TRMO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SCYGR10 →	+0.182	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	OR1A1 →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	LCE2A →	+0.038	+5.209	<.001	.005	3	1
BREAST	PZP →	+0.376	+4.421	<.001	.004	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

SCYGR10 by TRMO expression — PANCREAS

Explore this box plot interactively →