TRMO

Across TCGA pan-cancer cohorts, TRMO RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRMO’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TRMO RNA is repressed in tumor relative to normal tissue. In most cancer types TRMO is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LIHC are the cancer types where TRMO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRMO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.324	<.001	11	view →
LUAD	All	III,IV	−0.618	<.001	11	view →
LIHC	Male	II,III,IV	+0.717	<.001	9	view →
HNSC	Male	IV	+0.662	<.001	8	view →
COAD	All	All	+0.253	.001	7	view →
STAD	All	II,III,IV	+0.370	.001	6	view →
LUSC	All	All	−0.328	<.001	5	view →
BRCA	Female	II,III,IV	−0.280	<.001	4	view →
KICH	All	All	−0.501	.003	3	view →
CHOL	All	All	+0.834	.001	2	view →
UCEC	All	All	−0.505	.001	2	view →
KIRP	All	All	−0.253	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRMO–THCA

Open the THCA breakdown →